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KMID : 0602620010070020201
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Korean Journal of Hepatology
2001 Volume.7 No. 2 p.201 ~ p.205
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Combined Hepatocellular and Cholangiocarcinoma, Separate Type - A Case Report
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Abstract
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Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC that separately developed in a
patient
who
was serologically positive for hepatitis B virus. A 36-year-old woman was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein (AFP)
level,
a preoperative diagnosis of hepatocellular carcinoma was made. A left lobectomy of the liver was done. On histological examination, the resected tumor was shown to consist of two separated masses. One was hepatocellular carcinoma that showed
immunoreactivity for AFP. The other was cholangio- carcinoma that showed immunoreactivity for cytokeratin-19 (CK-19) in a separate form.
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KEYWORD
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